SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner

Abstract Protein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings.The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes in an H3K4me3-dependent manner have been well described in previous reports.Besides read more H3K4me3, H4K20me3 is another catalytic pr

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Assessment of neuropathic pain management knowledge, attitudes, and practices among urology trainees and consultants in prostate cancer care: a survey-based study

Abstract Background Effective neuropathic pain management is crucial in improving the quality of life for patients with prostate cancer.There is an abundance of research about cancer pain and guidelines that have been developed by World Health Organization including the analgesia stepladder, yet patients with cancer pain are still sub optimally ana

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3D shape measurement based on structured light field imaging

In this paper, a three-dimensional (3D) shape measurement method based on structured light field imaging is proposed, which contributes to the biomedical imaging.Generally, light field imaging is challenging to accomplish the 3D shape measurement accurately, as the slope estimation method based on radiance consistency is inaccurate.Taking into cons

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The Potential Therapeutic Effect of Orexin-Treated versus Orexin-Untreated Adipose Tissue-Derived Mesenchymal Stem Cell Therapy on Insulin Resistance in Type 2 Diabetic Rats

Type 2 diabetes mellitus is a chronic metabolic disease characterized by resistance to peripheral insulin actions.Mesenchymal stem cells have been studied for years in T2DM therapy, including adipose tissue-derived mesenchymal stem cells (AD-MSCs).Orexin neuropeptides (A and B) are well-known regulators of appetite and physical activity.The aim of

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